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Additionally, a meta-analysis found that Post-traumatic Stress Disorder (PTSD) is underpinned by the presence of a systemic low-grade inflammation that can lead to higher CRP, whereas other authors discuss that although there are consistent data regarding the relation between CRP and the potential risk and symptomatology of PTSD, there is a paucity of evidence on how CRP could contribute to CNS inflammation and further symptomatology in PTSD cases [640,641]