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2010;133(Pt 3):82234

Finally, do we have a solution

Gluten and casein release opioid peptides, which alter patterns of DNA methylation and gene expression and promote inflammation in the gastrointestinal (GI) tract [157]

The peptide P4-9 did potentiate the effect of antibiotic novobiocin in a process the authors referred to as Post-Antibiotic Effect-associated Permeabilization. Similarly, administration of other antibiotics such as macrolide, cephalosporins, ciprofloxacin, rifampin, and fosfomycin after the withdrawal of P4-9 also showed Post-Antibiotic Effect-associated Permeabilization at a varying magnitude