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Effects of testosterone treatment in older men
Additionally, it acts as a key inhibitor of ferroptosis, displaying distinct properties
To avoid these undesired cellular destructions, organisms have evolved the glutathione-dependent glyoxalase pathway 3 and NAD(P)H-dependent Aldo-Keto reductase pathway 11
The authors hypothesised that xCT inhibition might be further potentiated by limiting glutamate or glutamine availability, and show that xCT is a compelling therapeutic target for triple-negative tumours
