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This syndrome occurs when the cauda equina nerves, which are located at the lower end of the spine, are compressed

Those activities result in neuronal hyperpolarization and suppressed release of neurotransmitters, including substance P and glutamate, thus attenuating nociceptive signal transmission [55,56,57,58]

It was first isolated and characterised by Professor Predrag Sikiric and his research group at the University of Zagreb in the early 1990s, with the foundational paper published in the Journal of Physiology (Paris) in 1993

Vitamin B12 (cobalamin) is vital for red blood cell production, nerve function, and energy metabolism