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nucleatum , binds to E-cadherin to trigger a decrease in -catenin phosphorylation and subsequent activation of -catenin-regulated transcription, leading to increased oncogenic MYC expression, which upregulates the expression of immunosuppressive programmed cell death ligand 1 (PD-L1) and CD47 in cancer cells [72]

CHREBP induces hepatic lipogenic gene expression, including expression of ME1, PGD, ACLY, ACACA, and FASN (Singh et al., 2024), where ME1 and PGD contribute to an increased cytoplasmic [NADPH]/[NADP + ], although, this increase is limited by the FASN-mediated oxidation of NADPH

Kocak, Y., et al