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CD4 + T cells exhibit the capacity to differentiate into both pro-inflammatory [T helper-1 (TH1) and TH17] and anti-inflammatory (TH2 and Treg) subsets ( Emerging evidence suggests that -Syn and microglia act synergistically to exacerbate T cellmediated neuroinflammation in the central nervous system ( + T cells and Th1 cells, enhancing TNF- production ( BL has emerged as an immunomodulatory factor influencing adaptive immune responses

Here, downregulated SIRT1 and its downstream direct target PGC1- were found in acinar cells, and our findings verified that SIRT1 is a downstream target of CBS in acinar cells induced by NaT

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