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NAD+ NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that plays a critical role in cellular metabolism, DNA repair, and anti-aging processes

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Probably, and the prescriber should be testing B12 periodically

31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%