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Description
Activation of the HIF pathway triggers transcription of more than 100 genes associated with angiogenesis and metastasis, such as VEGF, SDF-1, angiopoietin-1 (Ang-1), placental growth factor (PlGF), platelet-derived growth factor B (PDGF-B), stem cell factor (SCF), vascular endothelial cadherin (VE-cadherin), ephrin-B, CD31, semaphorin 4D (sema4D), plexinB1, integrins, MMPs, and nodal and endothelial VEGF receptors (VEGFR-1 and VEGFR-2) [82]
The most affected animals are sheep, cattle, horses and pigs
The use of BPC-157 remains within the scope of experimental research
Through a well-designed clinical research approach, the advancement of research on treating retinal diseases with TCM can be facilitated
