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Extended efficacy trials or regulatory approval have not followed

5b,c), indicating reduced collagen cross-linking

Abbreviations ARE: Antioxidant response element AD: Alzheimers disease BDNF: Brain-derived neurotrophic factor Arr2: Beta arrestin-2 BNIP3: Bcl-2/adenovirus E1B 19-kDa interacting protein 3 Cys: Cysteine CNTF: Ciliary neurotrophic factor CNS: Central nervous system Cul-3: Cullin-3 CX3CRL1: Chemokine fractalkine ETC: Electron transport chain GSH: Glutathione GSK 3-: Glycogen synthase kinase GCLC: Glutamate-cysteine ligase catalytic subunit GCLM: Glutamatecysteine ligase modifier subunit G6PD: Glucose 6 phosphate dehydrogenase GFAP: Glial fibrillary acid protein GR: Glutathione reductase GPe: Globus pallidus external GDNF: Glial-derived neurotrophic factor GSSG: Glutathione disulfide HO-1: Heme oxygenase-1 IL-: Interleukin-1 IDH1: Isocitrate dehydrogenase-1 Jmjd3: Jomonji domain-containing protein 3 Keap 1: Kelch-like ECH- associated protein 1 LAMP2: Lysosome-associated membrane protein 2 LRRK2: Leucine-rich repeat kinase 2 LPS: Lipopolysaccride LB: Lewy body MANF: Mesencephalic astrocyte derived neurotrophic factor MPPP: 1-methyl-4-propionoxy-piperdine MPTP: 1-methyl 4-1,2,3,6- tetrahydropyridine mGSH: mitochondrial glutathione ME: Malic acid mTOR: mammalian target of rapamycin NOX: NADPH oxidase NQO1: NAD(P) H: quinone oxidoreductase-1 Nrf2: Nuclear factor erythroid related factor NADPH: Nicotinamide adenine dinucleotide NDDs: neurodegenerative diseases OMM: Outer mitochondrial membrane OXPH: Oxidative phosphorylation PRDX3 and PRDX5: Peroxiredoxins 3 and Peroxiredoxins 5 Parkin: E3 ubiquitin ligase PINK 1: Pten-induced kinase 1 PGC-1: Proliferator-activated receptor gamma coactivator-1 alpha PPP: Pentose phosphate pathway QDs: Quantum dots ROS: Reactive oxygen Species RNS: Reactive nitrogen species SNpc: Substantia nigra pars compacta SRXN1: Sulfiredoxin-1 SOD2: Superoxide dismutase 2 SQSTM1: Sequestosome-1 TIGAR: TP53-inducible glycolysis and apoptosis regulator TNF-: Tumor necrosis factor- TLR4: Toll like receptor 4 TRX2: Thioredoxin UPDRS: Unified Parkinsons Disease Rating Scale References Ahmed SMU, Luo L, Namani A, Wang XJ, Tang X (2017) Nrf2 signaling pathway: pivotal roles in inflammation

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