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There are typically no immediate or uncomfortable withdrawal symptoms when you stop

N Engl J Med 330(15):10291035 Aquino-Glvez A, Gonzlez-vila G, Delgado-Tello J, Castillejos-Lpez M, Mendoza-Milla C, Ziga J et al (2016) Effects of 2-methoxyestradiol on apoptosis and HIF-1 and HIF-2 expression in lung cancer cells under normoxia and hypoxia

In contrast, astrocytes exhibit lower expression of pyruvate dehydrogenase (Laughton et al., 2007), which limits oxidative phosphorylation (Itoh et al., 2003) and reduces pyruvate utilization efficiency in the TCA cycle (Rahman et al., 2020)

Recent evidence suggests that, even among hyperthyroid patients, maintaining an adequate dietary iodine intake improves therapeutic outcomes, enhancing response to treatment, reducing recurrence, increasing remission rates, and providing better control of thyrotoxicosis compared with inadequate or excessive iodine intake [40,41,42]