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A number of drugs have been described that act as G protein-biased, i.e., selectively activate G proteins and not arrestins, or -arrestin-biased ligands, i.e., selectively activate arrestins and not G proteins

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As research in this area progresses, we may see the emergence of new combination therapies that revolutionize the treatment of metabolic disorders

DIAGNOSIS OF INCIDENT DEMENTIA AND ALZHEIMER DISEASE Members of the dementia cohort have been monitored for the development of stroke and dementia since their inclusion in the cohort.1 Participants were routinely administered a screening Mini-Mental State Examination at each biennial examination.16 Persons who scored below education-based cutoffs or who experienced a decline of 3 or more points on the Mini-Mental State Examination from the most recent previous examination were called back for a neurological and neuropsychological examination