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Through the fermentation of food, the microbiota releases metabolites and short-chain fatty acids, which have anti-inflammatory properties and contribute to intestinal homeostasis [40]

However, some individuals report experiences that suggest possible associations between B12 and anxiety-like symptoms in certain contexts: High-dose supplementation : Some individuals report feeling 'overstimulated' or experiencing changes in energy levels when initiating B12 supplements

For example, it is known that ferroptosis and other types of cell deaths (necroptosis and apoptosis) occur concurrently following ischemic and traumatic brain injury (Zille et al., 2017

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