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Common themes include rapid onset of anti-inflammatory effects (often within days), gradual improvement in function over weeks, and best results when combined with appropriate physical therapy and lifestyle modifications

This landmark report demonstrates rapid-onset antidepressant effects of ketamine dependent on the activation of the mTOR pathway and increased number and function of new spine synapses in the PFC of rats

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Mazzetti A.P., Fiorile M.C., Primavera A., Lo Bello M

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