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10.1001/jama.2008.600 JAMA

Many individuals taking tirzepatide for weight management may simultaneously use creatine to preserve or build lean muscle mass during caloric restrictiona reasonable approach given that GLP-1 receptor agonists can lead to loss of both fat and muscle tissue

Instruct patients to promptly report any unexplained muscle pain, tenderness or weakness particularly if accompanied by malaise or fever [see Warnings and Precautions (5.1), and Drug Interactions (7.1)]

[9] [13] With 60% of magnesium within the body found in the bones and 27% in the skeletal muscle, magnesium plays an essential role in maintaining the integrity of the musculoskeletal system