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Some guidelines recommend holding GLP-1 receptor agonists before procedures requiring sedation or general anesthesia to reduce the risk of aspiration, though specific recommendations may vary based on the procedure type and individual patient factors

Journal of Endocrinology (2002) 4

NAD+ isnt designed to be taken sporadically for a quick fix its meant to support a baseline level in your system over time

While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition