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or lower nausea is a priority (PT-141 causes less nausea than MT-2 at effective doses) PT-141 is FDA-approved (as Vyleesi) for HSDD in premenopausal women: this regulatory distinction provides additional clinical confidence for that specific indication Neither compound should be chosen by patients with any melanoma history: the dermatological risk profile applies to both as MC1R/MC3R/MC4R agonists The practical decision between Melanotan-2 and PT-141 usually comes down to whether the patient wants the tanning effect