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Thus, while IN chelation is promising for directly targeting the brain and CNS, it still requires careful consideration of formulation strategies (e.g., nanoparticle targeting or controlled-release systems) to improve site specificity, especially for drugs with a narrow therapeutic window
[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Roth W., Mohamadzadeh M
the load of free radicals
This approach tends to be the most efficient way to deliver the medication and may require placement at two levels or on both sides (bilateral)
