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231 Given that altered regulation of Cu, homeostasis has been associated with a variety of disease conditions, future studies are warranted in order to determine the precise mechanism by which Cu imbalance causes cellular damage, thus providing important new information that can be used to design treatments for preventing disease and/or slowing disease progression

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185 ThewkeD

Therefore, systematically examining these gaps in evidence is crucial for objectively assessing the reliability of this framework and guiding confirmatory studies
