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Meta-analysis did not, however, note a significant effect size for GPx [38]

Isatin ( 16 ), (+) - kavain ( 17 ), lapachol ( 18 ), Lawsone ( 19 ), juglone ( 20 ), menadione ( 21 ), 2-methoxy-1,4-naphthoquinone ( 22 ) and 1,4-naphthoquinone ( 23 ) as well as the reference inhibitor, chrysin, were obtained from Sigma-Aldrich

Because both CMI and its active metabolite, DMI, have long elimination half-lives, the prescriber should take into consideration the fact that steady-state plasma levels may not be achieved until 2 to 3 weeks after dosage change ( seeCLINICAL PHARMACOLOGY)

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