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ATM also phosphorylates multiple downstream targets (notably including, p53, -H2AX, CHK1 and CHK2) that are also involved in apoptosis, cell cycle regulation and DNA repair 47,48,49

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Targeted proteomics approaches revealed that many mitochondrial and cytosolic proteins were oxidatively modified upon exposure to MDMA, and some of them, like mitochondrial ALDH2, 3-ketoacyl-CoA, and ATP synthetase, were inactivated [198]

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