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Glutathione S-transferase Mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

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Due to the loss of the brain privilege for vitamin B2 supply, this inherited condition may be particularly relevant for CNS diseases such as migraine, brain ischemia, traumatic brain injury, neurodegenerative disorders (especially Parkinson and Alzheimers diseases), epilepsy, multiple sclerosis, and for Guillain-Barr syndrome, myasthenia, and mitochondrial myopathies