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Biomarkers of oxidative stress in pregnant women with recurrent miscarriages

1 Introduction Periodontitis is a globally prevalent chronic inflammatory disease triggered by dysregulation of oral biofilm and host immune responses, serving as the primary cause of adult tooth loss ( A multi-platform analysis of human gingival crevicular fluid reveals that ferroptosis is an associated regulated cell death mechanism during the clinical progression of periodontitis ( Porphyromonas gingivalis can actively induce ferroptosis through multiple pathways ( This review systematically summarizes the molecular mechanisms of ferroptosis in periodontitis, with a focus on how dysregulated iron metabolism, reprogrammed lipid metabolism, and suppressed antioxidant defenses in the periodontal microenvironment regulate ferroptosis

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Colloquially known as bench to bedside, these facts dont create cures by themselves but need to be recognized by researchers and leaders in the field in order to have a meaningful impact that can alter the natural history of disease