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Holden S, Maksoud R, Eaton-Fitch N, Cabanas H, Staines D, Marshall-Gradisnik S
These findings are similar to data recently published by us in clinical cohorts, with E4 carriers exhibiting relatively higher SCAs and lower LCAs with AD even at the pre-clinical stages compared to controls and other APOE genotypes (Huguenard et al., 2022)
Importantly, in addition to the intrinsic tumorigenic drive generated by the biallelic inactivation of this tumour-suppressor gene in the neoplastic cells, it has been suggested that a heterozygous tumour-suppressor microenvironment also modulates tumour progression

Romo VC, Lima A, Bernardes M, et al
