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Hill EL (2004) Evaluating the theory of executive dysfunction in autism

The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)

In the Gdap1 / mice, there is no change in M2 microglia (CD206+ve expression) typically associated with anti-inflammatory cytokines, debris clearance, and tissue repair