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This change may be diagnosed as cytologic alteration or mitotic alteration with a description in the pathology narrative

Improved ischemic tolerance of PHD2 deficient neurons is accompanied by augmented glucose uptake and glycolytic flux as well as glucose metabolism switch from oxidative phosphorylation to aerobic glycolysis in a HIF-dependent manner In order to elucidate whether potential HIF-dependent reprogramming of the neuronal metabolism contributes to the improved outcome after ischemic stroke, we first analyzed the expression of HIF target genes, whose function is related to glucose metabolism, in neuronal cultures derived from newborn nPhd2 / and nPhd2/Hif1a/Hif2a / mice

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Hope HC, Salmond RJ