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Broadly speaking, children tend to present with more acute, systemic symptoms, whereas adults tend to present with more chronic, localized symptoms

But the signaling system directing them may have become dysregulated

Alcohol-Related Liver Stress : People with a history of heavy alcohol use often have severely depleted glutathione stores and compromised liver function

Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release
