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To overcome this, SOD can be incorporated either in highly loaded conventional liposomes or long-circulating liposomes (PEG-liposomes).[85] Many SOD mimetics have been synthesized that can be used as pharmaceutical agents in a large number of diseases in which the native SOD is ineffective.[80,86] Potent SOD mimetics such as metalloporphyrins, Mn cyclic polyamines, Mn-salen derivatives, and nitroxides have been developed for treating various diseases resulting from increased oxidative stress.[87] Future perspectives Diets high in vegetables and fruits, which are good sources of antioxidants, have been found to be healthy

Table 2 Summary of association studies between genetic polymorphisms on Glutathione-S-Transferases and outcomes in the cisplatin-based chemotherapy

Glutarate may form more stable adducts compared to succinate, as suggested by the self-hydrolysis observed with the Lp suc peptide compared to the Lp glu form