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This gut-lung interorgan communication mechanism demonstrates significant clinical relevance in chronic respiratory diseases, with large-scale cohort studies establishing a strong inverse correlation between gut microbiota -diversity reduction and key clinical parameters including asthma exacerbation frequency and annual lung function decline in COPD (Tangedal et al., 2024)

Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress-mediated mitochondria and endoplasmic reticulum-dependent apoptotic death

Process A was conducted in two sequential steps

Firstly, one of the primary obstacles is the absence of reliable biomarkers in PF patients that can accurately indicate the extent of lipid peroxidation and ferroptosis, making it difficult to assess disease severity and progression