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In some studies, combining azelaic acid with a retinoid (like tretinoin) or glycolic acid produced faster or greater lightening of melasma than azelaic acid alone

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During oncogenic transformation of hematopoietic cells, chromatin-bound CDK6 phosphorylates NFY and SP1 transcription-factors and induces expression of p53-antagonists such as PRMT5, PPM1D and MDM4 (42)

Aceves C, Anguiano B, Delgado G: The extrathyronine actions of iodine as antioxidant, apoptotic, and differentiation factor in various tissues