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This results in the accumulation of electrons which can trigger ROS generation, as well as an accumulation of acyl-CoA which further disrupts mitochondrial function and signaling

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Given the important role of the carnitine pool in numerous metabolic functions, changes in its levels may serve as powerful biomarkers for the early identification or prediction of pathological states related to visual impairment

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In TMAO-treated macrophages, significant upregulation is observed in both M1 signature cytokines (including IL-1, IL-6, TNF-, Chemokine (C-X-C motif) ligand (CXCL) 9, and CXCL10) and key genes such as NLRP3 (77)

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