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[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Jr, Hallows KR, Brown D, Bouley R, Vilardaga JP
GSH depletion exacerbates ROS buildup, leading to oxidative damage, impaired insulin secretion, and eventual -cell apoptosis
Furthermore, HPP971 has completed two phase-I studies for the treatment of several diseases, including blood, bone, eye, kidney, and lung diseases, where it was well tolerated [66]
Nearly maximum inhibition in the expression of GSH synthetic enzymes occurred as early as six hours after LPS administration [163]
