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Abstract Rett syndrome (RTT, OMIM 312750), a severe neurodevelopmental disorder characterized by regression with loss of spoken language and hand skills, development of characteristic hand stereotypies, and gait dysfunction, is primarily caused by de novo mutations in the X-linked gene Methyl-CpG-binding protein 2 ( MECP2 )

Administration of ketones after controlled cortical impact injury in young rats reduced lesion volume, attenuated motor and cognitive deficits, reduced cellular apoptotic markers, and improved cerebral ATP levels (Prins et al., 2005

It is synthesized from the amino acids lysine and methionine, while smaller amounts are also obtained from foodprimarily animal-based sources
