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Abstract The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented concentration of economic and research efforts to generate knowledge at unequalled speed on deregulated interferon type I signalling and nuclear factor kappa light chain enhancer in B-cells (NF-B)-driven interleukin (IL)-1, IL-6, IL-18 secretion causing cytokine storms

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Additionally, in hormone receptor-positive breast cancer, the most common modification in the PI3K/AKT/mTOR signaling pathway is the loss of PTEN [88], which is a pivotal regulator in the PI3K/AKT/mTOR pathway involved in cell growth and survival, cell migration, and genomic stability [89]