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Disbrow JK, Gershten MJ, Ruth JA
E.LoscalzoJ
Acute complete depletion may rapidly amplify oxidative stress and cell injury, whereas more gradual depletion appears to allow for more selective redox remodeling without overwhelming stress responses, although further studies including comprehensive transcriptomic and epigenomic analyses will be necessary to dissect the differential regulatory networks altered by different modes of GSH depletion
Figure 1 This schematic illustrates the key molecular mechanisms contributing to dopaminergic neuron degeneration in Parkinsons disease (PD)
