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While standard skin-directed therapies are effective for individuals with indolent early-stage disease, patients with more advanced or refractory forms require systemic treatments, which may consist of chemotherapy, retinoid analogs, interferons, HDAC inhibitors, and antibodies 1,2,3,4

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10.1186/s12967-023-04773-5 114 JoS.ChengX.LeeJ.KimS.ParkS