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The study showed lesser scores on the Mini-Mental Status Exam (MMSE) and higher depression scores among patients with lower plasma levels of Vitamin B12 [25]

This was along with counteraction of clopidogrel-induced down-regulation of the VEGF-A and VEGFR1 , subsequently inactivated AKT signaling pathway, and induced phosphorylation of p38/MAPK and ERK/MAPK [92]

The gip2 oncogene (for G i protein) promotes tumour growth by activating mitogen-activated protein kinase (MAPK) pathways [ 10 ], while mutationally activated forms of G z , G q , G 12 and G 13 are able to generated transformed phenotypes [ 10 , 11 ]

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