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Treatment of 4.2 / mice with mitapivat significantly increased hematocrit (Hct) and Hb values, and Hb to RBC distribution width (RDW) ratio, a complementary RBC index for spherocytosis and dense RBCs, when compared with vehicle-treated animals (Figure 2A)

The red cells may completely lack HbA ( 0 / 0 genotype) or contain small amounts ( + / + or 0 / + genotypes)

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