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It is believed that increased immune activation induced by CTLA-4 blockade may trigger a compensatory response that leads to an increased IDO expression, further contributing to immune exhaustion (234)
Thus, motifs 1 and 5 are characteristic of the ATP-binding region of the ATP-grasp superfamily enzymes
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doi: 10.1128/mcb.00688-08
doi: 10.1038/ncomms14844 83 YePMimuraJOkadaTSatoHLiuTMaruyamaAet al
