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Kelch-like Ech-associated Protein-1 (KEAP1) keeps Nrf2 tethered in the cytoplasm, where it is degraded in an unstressed state by the ubiquitinproteasome system

What we do not know : Higher doses may be more effective but may cause more side effects

Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions

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