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426 Prolonged PARP activation also couples NAD + and ATP depletion, thereby triggering cellular energy crisis and metabolic reprogramming

To model the inflammatory conditions associated with liver injury, WT and FBXL5 KO cells were treated with lipopolysaccharide (LPS), a ligand for Toll-like receptor 4 (TLR4), to induce IL-6 expression in DC2.4 cells in vitro

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