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Turner, N.W., Bramhmbhatt, H., Szabo-Vezse, M., Poma, A., Coker, R., and Piletsky, S.A., Anal

Activation of PKC has been determined to lead to inhibition of glomerular endothelial cell function, increased phosphorylation of Erk1/2, decreased activation of endothelial nitric oxide synthase in the glomerulus and endothelial dysfunction may lead to loss of antioxidant and inflammatory effects of nitric oxide, thereby aggravating DKD

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