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Cancer cell vulnerability during metastasis Metabolic plasticity and cancer stemness The high metabolic plasticity and oxidative damage resistance of CSCs can be attributed to the evolutionary selection during metastasis that is fated to happen when the primary tumor site could not meet the nutritional requirement of the ever-growing tumor body (Fig

Therefore, transformed cells need to overcome the oxidative stress before colonizing in the lung [132,133,134]

Next, we investigated expression of SLC7A11 mRNA in SMARCA4-, SMARCB1-, and PBRM1-deficient cell lines and found that levels of SLC7A11 protein (Fig

[19] suggested that these fibers, termed as MIAs, likely contribute to mechanical hyperalgesia