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Cai Q, Zakaria HM, Simone A, Sheng Z-H

Depression and anxiety disorders have been reported to co-occur with cardiovascular disease, trauma and numerous forms of cancer, such as lung cancer, breast cancer and malignant brain tumors (89)

While Nrf2 signaling is often suppressed globally in COPD lungs, its dysfunction in macrophages may paradoxically promote ferritinophagy-mediated iron retention through nuclear receptor coactivator 4 (NCOA4), overwhelming ferroprotein (FPN)-mediated iron export and unintentionally fueling ferroptosis

As the bodys own antioxidant, it plays a central role in protecting against oxidative stress and detoxifying harmful substances