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Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis

Moreover, the gut-muscle axis is being elucidated, with evidence suggesting that gut-derived hormones like Ghrelin may not only stimulate appetite but also have direct anti-inflammatory and anabolic effects on skeletal muscle, with potential secondary benefits for vascular health (133) (As shown in Figure 5 )

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study

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