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While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

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doi:10.1023/B:BEBM.0000038164.49947.8c PMID: 15455129 Anisimov VN, Khavinson VKh, Provinciali M, et al

doi: 10.1016/s0006-2952(97)00494-2
