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Abbreviations Used 2-AG 2-arachidonoylglycerol A 2A adenosine A 2A APO A apolipoprotein A BDS botanical drug substance BMI body mass index CB1 cannabinoid receptor 1 CB2 cannabinoid receptor 2 CBC cannabichromene CBD cannabidiol CBDA cannabidiolic acid CBDV cannabidivarin CBDVA cannabidivarinic acid CBG cannabigerol CBGA cannabigerolic acid CBGV cannabigerivarin CBN cannabinol CI confidence interval CNS central nervous system CS Cannabis smoking DIO diet-induced obese DM diabetes mellitus DPCPX cyclopentyl-1,3-dipropylxanthine ECS endocannabinoid system GLUT4 glucose transporter isotype 4 HDL high-density lipoprotein I.P

This resulted in normalization of the tGSH:GSSG ratio, also known as the glutathione redox profile

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Even though it is not always possible to distinguish between activity of GHK peptide and its copper complex GHK-Cu, we strongly believe that for the future therapeutical applications GHK-Cu should be used