cysteine based glutathione What is Glutathione? – GoldBio Figure 2 from Role of

Delphinidin, a potent and abundant anthocyanin found in berries, can activate the NRF2 promoter by promoting its demethylation

B12 inclusion addresses the nutritional component of fatigue but does not fully prevent the physiological adaptation period

Much of the glutathione is broken down in the digestive tract before it can reach systemic circulation

Enzyme-responsive type In contrast to enzyme-responsive drug carriers (see above) where enzymatic cleavage releases small-molecule drugs from carrier matrices, the approaches in this subsection employ enzymatic reactions to directly destabilize the lysosomal membrane, facilitating escape of the carrier and its macromolecular cargo