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GOLD 2016 particularly pointed cough with sputum as an independent factor associated with increased mortality in mild-to-moderate COPD patients

CRP is produced by the liver in response to inflammatory signals throughout the body

[DOI] [PubMed] [Google Scholar] 199.Yamamoto A., Bhuiyan M.N.H., Waditee R., Tanaka Y., Esaka M., Oba K., Jagendorf A.T., Takabe T

However, in PM, it appears that IL-6 is not directly associated with promoting pleocytosis in the CSF but rather with brain edema, BBB disruption, and increased intracranial pressure (46)
