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The most frequently occurring keyword is oxidative stress (22 occurrences), followed closely by H (18) and inflammation (13), underscoring the predominant focus on redox regulation and inflammatory modulation

Initiation of treatment in patients with NYHA Class III or IV heart failure is CONTRAINDICATED

Nevertheless, challenges exist, such as limited response in some patients owing to tumor heterogeneity and immune evasion mechanisms, development of resistance (primary or acquired), immune-related adverse effects (such as cytokine release syndrome), high cost and the need for sophisticated infrastructure (for a review, see 740 )

This effect is usually mild and brief, lasting minutes rather than hours