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Interestingly, the combination of vitamins A, C, and E administered orally to patients did not show any effect over music-induced TTS (Le Prell et al., 2016)

By inducing mild oxidative stress, they can activate endogenous defense systems, particularly the Nrf2 pathway, which plays a central role in regulating antioxidant responses

NRF2 activity is also regulated by the availability of many binding partners, including a group of bZIP bi-directional transcription regulators named sMaf proteins (MafF, G and K) [200, 201] which, when bound to NRF2, under OS, favor its maintenance inside the nucleus thereby enhancing its activity [202]

Examples include syntheses from S-malic acid [44] or D-mannitol [45]